Two marine algae (Acanthophora spicifera and Padina tetrastromatica) collected from Madapam coastal areas, Rameshwaram, India were screened for antibacterial activity and minimum inhibitory activity. The seaweeds were extracted by using five different solvents i.e Dichloromethane, Methanol, Hexane, Diethylether and Acetone. All the seaweeds were evaluated antimicrobial activity and minimum inhibitory concentration. The cured compound of Acanthophora spicifera and Padina tetrastromatica was analysis by FTIR. Padina tetrastromatica was analysised by GC MS. Based on the antibacterial and minimum inhibitory concentration diethyl ether extract of P. tetrastromatica and Methanol extract of A. spicifera showed a better zone inhibition and lowest MIC level against the human pathogens. The cured bioactive compound of diethylether extract of P. tetrastromatica and methanol extract of A. spicifera were analysis by FTIR. Di ethyl ether extract of P. tetrastromatica was analysised by GCMS. Based on the GCMS result P. tetrastromatica the active cured extract was composed of volatile metabolites and fatty acids. Most of the seaweeds contain fatty acids. In this fatty acids show a good antimicrobial activity against human pathogen. Based on the FTIR and GCMS results clearly show that seaweeds P. tetrastromatica are an interesting source for biologically active compounds that may be applied for prophylaxis and therapy of human infection, these compounds could be utilized for the development of medically potential products.
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